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ea0077ec1.2 | Early Career Prize Lecture Basic Science (1) | SFEBES2021

Cardiometabolic disease burden and urine steroid metabolome in benign adrenocortical tumours: a case-control study

Prete Alessandro , Subramanian Anuradhaa , Bancos Irina , Chortis Vasileios , Tsagarakis Stylianos , Lang Katharina , Macech Magdalena , Delivanis Danae A , Pupovac Ivana D , Reimondo Giuseppe , Marina Ljiljana V , Deutschbein Timo , Balomenaki Maria , O’Reilly Michael W , Bednarczuk Tomasz , Zhang Catherine , Dusek Tina , Diamantopoulos Aristidis , Asia Miriam , Kondracka Agnieszka , Li Dingfeng , Masjkur Jimmy R , Quinkler Marcus , Ueland Grethe AE , Dennedy M Conall , Beuschlein Felix , Tabarin Antoine , Fassnacht Martin , Ivovic Miomira , Terzolo Massimo , Kastelan Darko , Young Jr William F , Manolopoulos Konstantinos N , Ambroziak Urszula , Vassiliadi Dimitra A , Taylor Angela E , Sitch Alice J , Nirantharakumar Krishnarajah , Arlt Wiebke

Background: The overwhelming majority of incidentally discovered adrenal tumours are benign adrenocortical adenomas. These can be non-functioning (NFAT) or associated with cortisol excess on a spectrum ranging from rare clinically overt adrenal Cushings syndrome (CS) to much more prevalent mild autonomous cortisol secretion (MACS) without signs of CS. The 1mg-overnight dexamethasone suppression test (DST) further differentiates MACS-1 (possible MACS; post-DST cortisol 50...

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ea0086oc4.4 | Adrenal and Cardiovascular | SFEBES2022

Steroid and global metabolome in benign adrenal tumours with mild autonomous cortisol secretion: analysis by mass spectrometry and machine learning to understand metabolic risk

Prete Alessandro , Abdi Lida , Canducci Marco , Taylor Angela E. , Bancos Irina , Gilligan Lorna C. , Jenkinson Carl , Albors-Zumel Ariadna , van den Brandhof Elina , Zhang Yuanqing , Chortis Vasileios , Tsagarakis Stylianos , Lang Katharina , Macech Magdalena , Delivanis Danae A. , Pupovac Ivana D. , Reimondo Giuseppe , Marina Ljiljana V. , Deutschbein Timo , Balomenaki Maria , O'Reilly Michael W. , Bednarczuk Tomasz , Zhang Catherine D. , Dusek Tina , Diamantopoulos Aristidis , Asia Miriam , Kondracka Agnieszka , Li Dingfeng , Masjkur Jimmy R. , Quinkler Marcus , Ueland Grethe AE. , Conall Dennedy M. , Beuschlein Felix , Tabarin Antoine , Fassnacht Martin , Ivovic Miomira , Terzolo Massimo , Kastelan Darko , Young Jr William F. , Manolopoulos Konstantinos M. , Ambroziak Urszula , Vassiliadi Dimitra A. , Sitch Alice J. , Tino Peter , Biehl Michael , Dunn Warwick B. , Arlt Wiebke

Background: Benign adrenal tumours are found in 3-10% of adults and can be non-functioning (NFAT) or associated with adrenal hormone excess. Analysing 1305 prospectively recruited patients with benign adrenal tumours, we recently demonstrated that 45% had mild autonomous cortisol secretion (MACS), i.e. biochemical cortisol excess without signs of Cushings syndrome (CS). MACS increases the prevalence and severity of hypertension and type 2 diabetes (Ann Int Med. 2022 Doi:...

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Endocrine Abstracts

Cardiometabolic disease burden and urine steroid metabolome in benign adrenocortical tumours: a case-control study

Steroid and global metabolome in benign adrenal tumours with mild autonomous cortisol secretion: analysis by mass spectrometry and machine learning to understand metabolic risk

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